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pentobarbital decreases amounts of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers boost fee of toremifene metabolism, decreasing the regular-condition concentration in serum.pentobarbital will lower the level or effect of vinorelbine by influencing hepatic/intestinal enzyme CYP3A4 metabolis